I know that wasn’t the point, but:

Holt as Sisko and Terry as Worf is cool (Holt might work better as Odo, but we’ll get to that in a sec).

Rosa should be Kira (Worf looks mean but is a big softy, hence Terry. Kira is the one that will kick your ass if you piss her off), Jina as Quark (obviously), Amy as Odo, Boyle as Rom, Hitchcock and Scully as O’brian and Bashir in their “two buds going to the holosuite to pretend they’re WW1 pilots” mode.

Jake works surprisingly well as Jadzia - both like to do silly things, kinda offbeat yet very good at their job.