I would not recommend using your primary desktop for self hosting. If you just absolutely have to, install Virtual Box or some other hypervisor solution and run your servers in separate VM's.

Use a dedicated host. It can be a desktop, server, Raspberry Pi, etc. Depending on your needs. Sooner or later you'll find that hosting on a workstation that you use for other things is horribly inconvenient. Depending on what you're self hosting, it can consume lots of resources. If you become dependent on the services you're hosting, which is the point of self hosting to begin with, even really small things like rebooting your workstation can become really inconvenient.

I've got an old Dell PowerEdge ticking away in my basement that runs all my VM's. I can reboot my desktop without interrupting any of my self hosted services. It also makes it easier to back up my VM's and I can easily spin up a new one if needed. You have to be careful if you use server hardware though. The T430 that I have is pretty efficient but some servers can be thirsty little space heaters.