That’s pretty impressive. I hadn’t even thought oral treatments were possible!

It’s amazing.

Are we both talking about the original game for Nintendo 64? Because that sounds like a bit of an overstatement to me if that’s the case.

Or am I remembering something wrong?

Doesn’t look bad at all, but aren’t Paper Mario and Mario & Luigi series RPGs?

Feels weird to use them as examples for inspirations for a platformer.

Feels more like Yoshi’s Island elements thrown into a 2D version of Super Mario 3D World.

It must have been over 5 years ago. It turned me off. The culture there was so painful. People would refuse to answer a question just because they deemed the premise of your question unacceptable. Or even recommend you change your whole project’s language.

It was like that both in questions and in chat. I never tried again.

CRISPR makes gene editing easier, but unless you’ve got a way to deliver it to every cell, it won’t do much unless you’re targeting such a small number of cells that it’s realistic to have a technician physically inject it into a cell.

That would work for an embryo. Ignoring the plethora of ethical issues and the lack of data on long-term effects, it would probably be pretty easy for a scientist to make the change in an embryo and then go through the normal in-vitro fertilization procedure.

For a whole organism, though, it’s more difficult. One obvious solution is a specially modified virus, and that’s under research.

There’s a lot of stuff here if you want to dive deep:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356196/#sec3-biomolecules-10-00839title

It’s speculation, but from my experience with Accutane I can infer the following possibility:

• an earwax blockage could get worse because of dry earwax depending on the particular ear

Also speculation:

• if there’s fewer lipids in sweat, you keep those fats, and potentially you lose less weight.

Well there’s a pretty easy fix unless it’s an extreme case. Razor and antiperspirant (or just deodorant if you’re worried about aluminium).

Maybe she’s used to it. Maybe it’s not that bad to her. Or maybe she just thinks it’s impolite to point it out.

Maybe you’re right and you really don’t smell much. But most cases I’ve seen actually did smell.

For a few months, while I was taking Accutane, my earwax turned dry and flaky. It was awesome. It would come out much more easily, it wouldn’t accumulate, and for once my ears stopped producing so much liquid. But I imagine depending on your unique body, it could make things quite a bit worse if you manage to get an earwax blockage.

Disclaimer: do not take Accutane for more than a few months, unless your doctor really knows what they’re doing. Apparently there are significant risks associated with long-term usage.

And pure speculation, but I imagine if you’re not excreting that fat, you might lose a tiny bit less weight when exercising?

We can do this on isolated cells, but I really don’t think we have a way to distribute such a change across the zillions of cells in a human body.

And even if we could, it’s not clear how much effect altering the gene after the fact would have. Maybe once your apocrine glands have obeyed the gene and developed a certain way, it’s too late.

That said… Sign me the hell up.

Final Fantasy X blew my mind in pretty much every way possible. Never had I seen such amazing graphics, heard such great video game music, been immersed in such a gripping story in a game.

Honestly I think I may have been chasing that high ever since.

So which instance an account is from matters regarding which communities you can join? Huh.

I heard what lemmy is. I googled Lemmy. I downloaded an app. I pressed sign up. I ended up on Lemmy.world.

I’ll be honest I don’t even really understand what different instances do.